Suggest me some horror within these parameters

-No big serial names like King, Koontz, etc.
-No supernatural, possession, religion stuff
-A unique premise or very different twist on something that's been done
-I live sci-fi, so if it's SF horror, bonus points

I've read Blindsight. I'm about to read Blood Music by Greg Bear. I have Bad Brains by Koja in my Kindle. Thanks!