What are some novels whose major theme(s) would be inherently shattered if given a visual adaptation?

I'm talking even if given massive budgets, given competent directors and staff, etc. Which stories are just intrinsically unadaptable into visual mediums no matter what?

And not because a character would look a certain way that doesn't match your headcanon, or not because a tiny moment in the story would have to change, but because the core tenets of the story somewhat rest upon not having visuals.